Hard Hat Area: For those working with HLA gene encoding...online tool with a statistical approach that can use existing high quality HLA data to reduce ambiguity in lower quality data sets...now if you get all of this and this is your specialty, use the link below to try the online tool...if not, just skip to the next article....BD
Microsoft Research and several collaborators have developed an in silico method to probabilistically refine low-resolution human leukocyte antigen-typing data that could potentially aid vaccine design, transplantation medicine, and immunology research, according to a recent study.
In a paper published in the February PLoS Computational Biology, the research team, which included scientists from Microsoft, Massachusetts General Hospital, the National Cancer Institute, and the University of Oxford, reported that the new method outperformed the multinomial-based approach that the HLA community currently uses to refine data.
A software package based on the approach, the HLA Completion tool, is available here.
BioInform: Microsoft Research and Partners Develop Tool to Refine Low-Res HLA-Typing Data
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