I really like this simple application and became acquainted with it last year at a Microsoft Tech Net meeting. Although a tablet is ultimate, it works on any PC. If you have already found ZoomIt, this might offer you an update at the site. When doing projected demonstration is works very well to magnify selected portions of the screen and being able to use some ink on the screen makes any presentation better focused. 
Using the inking on medical images could be very helpful and the inking is only scratchpad and is not permanently annotated. Does not require an installation so it would work on a portable drive as well. BD
ZoomIt is screen zoom and annotation tool for technical presentations that include application demonstrations. ZoomIt runs unobtrusively in the tray and activates with customizable hotkeys to zoom in on an area of the screen, move around while zoomed, and draw on the zoomed image. I wrote ZoomIt to fit my specific needs and use it in all my presentations. ZoomIt works on all versions of Windows and you can use pen input for ZoomIt drawing on tablet PCs.
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