The research is strong enough and substantiated to earn a patent for their discovery so in time perhaps we might be sniffing our way to sleep. I happen to like the smell of Jasmine myself so no problem there and I wonder if Jasmine will become a “controlled substance” in time. I hope not as I like growing it in my back yard.
This also stands to give a new meaning to aromatherapy. The researchers also hope to achieve stronger effects by changing the chemical structure so we can look forward to Jasmine or Jasmine Extra Strength in the near future (grin). This would be nice if the habit forming properties are not prevalent as they are in the drugs we take today. BD
In collaboration with Dr. Olga Sergeeva and Prof. Helmut Hass from the Heinrich Heine University in Düsseldorf, researchers from Bochum led by Prof. Hanns Hatt have discovered that the two fragrances Vertacetal-coeur (VC) and the chemical variation (PI24513) have the same molecular mechanism of action and are as strong as the commonly prescribed barbiturates or propofol. They soothe, relieve anxiety and promote sleep.
The RUB researchers have now performed a large screening study in which they tested hundreds of fragrances to determine their effect on GABA receptors in humans and mice. The two fragrances vertacetal-coeur (VC) and the chemical variation (PI24513) were the strongest: they were able to increase the GABA effect by more than five times and thus act as strongly as the known drugs. The "cross check" with genetically modified GABA receptors in transgenic mice which no longer responded to propofol confirmed that the mechanism of action is the same: the altered receptor also no longer responded to the fragrances.
"We have discovered a new class of GABA receptor modulator which can be administered parentally and through the respiratory air," says Prof. Hatt. "Applications in sedation, anxiety, excitement and aggression relieving treatment and sleep induction therapy are all imaginable. The results can also be seen as evidence of a scientific basis for aromatherapy." By changing the chemical structure of the scent molecules, the researchers hope to achieve even stronger effects