Ok with the title a little sarcasm but I really didn’t know that this was a specific type of constipation and that a special drug was needed for relief? As you read the article the design of the drug is to ensure you don’t lose any painkilling ability of the Opioid drug. I didn’t even
know that was a side effect of taking a drug to relieve constipation if one were taking an Opioid. Guess the ones off the shelf are not as good anymore?
The drug is due to release the first quarter of 2015 and was first approved to treat severely ill patients receiving palliative care where the off the shelf remedies did not provide relief. The drug is not for patients being treated for cancer. BD
(Reuters) - The U.S. Food and Drug Administration approved an oral therapy to treat opioid-induced constipation developed by Nectar Therapeutics and AstraZeneca Plc .
The decision opens the door for peripherally acting mu opioid receptor antagonists, which have been linked with cardiovascular risk in the past.
This class of opioid-induced constipation (OIC) drugs are designed to fight the effects of opioid painkillers on the gut without compromising centrally mediated pain relief.
The agency on Tuesday asked the developers to conduct a postmarketing study to further evaluate the potential risk of heart-related side-effects.
"If you look at the way they structured the deal with Nektar, clearly they think this is a multi-billion dollar drug," he said.
http://www.reuters.com/article/2014/09/16/astrazeneca-fda-idUSL3N0RG4TT20140916
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