This is the news I think everyone would welcome, but thus far it works with mice, but then again the breakthrough is fairly new and of course it would have to be evaluated for potential side effects as well before it ever comes to market. So far it is keeping mice from getting fat. BD
A European and American study on a new synthetic drug found that it protected laboratory mice from diet-induced obesity and its potential consequences like glucose intolerance and insensitivity to insulin by activating an enzyme that promoted fat consumption and exercise endurance, leading to suggestions that it could be an important new weapon in the fight against obesity and diabetes.
The study was led by professor Johan Auwerx of the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland and the experimental new drug, SRT1720, is made by Sirtris, a company based in Cambridge, Massachusetts that was acquired by GlaxoSmithKline earlier this year. The findings are published in the 5 November issue of Cell Metabolism.
The interest in SIRT1 as a target for drug development has been increasing in line with the view that diet and exercise is often not enough to reduce obesity and related metabolic disorders like diabetes.
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