Your DNA will be tested for GRK3 and two of its genetic variations and yes you receive a “spit kit” for your deposit.  The site also states the test is only available for those individuals showing symptoms, so if you are not in that category, the test is not for you.  I would also think that it would be a good idea though to consult with your doctor first and work as a team rather than just placing a mail order for the interpretation. 

Probably more important to find out is if serotonin-based drug treatment would be genetically acceptable for use.  If the economy doesn’t shape up soon, we might all be thinking about a test (grin).  I did a another post and someone asked me about the test, so here it is if thisimage proves to be helpful.  As it states below they suggest the test if one was considering anti-depressants, and it won’t tell you if you will develop bi-polar, that part I guess is still a surprise.  BD 

From the website: 

Psynome™ – tests for two mutations in the GRK3 gene that are associated with bipolar disorder. Patients who have either of these two mutations, are Caucasian, of Northern European ancestry and have a family history of bipolar disorder, are three times more likely to have bipolar disorder. The price for the Psynome test alone is $399. 

Psynome2™ – tests for mutations in the Promoter L allele gene that predicts patient response to serotonin-based drugs, the most commonly prescribed drug therapies today. No other DNA test exists today to identify an individuals positive or negative response to SSRIs. The serotonin transporter gene is associated with response to SSRI antidepressants, as well as, several other traits including vulnerability to stress induced major depression. Patients with one of two genotype mutations that are Caucasian and suffering from depression, are twice as likely to benefit from treatment with an SSRI type of antidepressant. The price for the Psynome2 test alone is $399.

The identification of each new gene, added to the current list of patented genes, will continue to improve the specificity, sensitivity and diagnostic accuracy and lead to a greater understanding of these diseases. Future genetic discoveries and collaborative relationships will allow Psynomics to expand the range of its tests to include other mental disorders.
The company will not test individuals who have no symptoms but want to know their likelihood of developing bipolar disorder.
  • It does not tell you if you will develop bipolar disorder in the future.
  • It does not tell you if your children will develop a mood disorder
    • You Should Consider Testing If:
      • You have had problems with depression, mania or irritability and want to know if you have a genetic predisposition to bipolar disorder and whether you should seek treatment.
      • You are currently being treated for depression or bipolar disorder and you and your doctor want state-of-the-art DNA testing to help confirm your diagnosis and choose the best treatment.
      • You are being treated for depression and your doctor would like to test you for possible bipolar disorder
      • You and your doctor would like to know how you will likely respond to serotonin-based drug treatments.
      • You are being treated, but want a second opinion regarding your diagnosis and treatment.
      • You are being treated with, or are considering treatment with, antidepressants.
      • You would like to learn more about the possible role of genes for mood disorder in your illness and in your family.


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