I say combination as we are back to the horse urine and adding receptors that block estrogen actions with breast cancer cells so perhaps the combinationimage was found to give relief for hot flashes and stop the estrogen breast cancer risks? 

“As their name says, SERMs are "selective" – this means that a SERM that blocks estrogen's action in breast cells can activate estrogen's action in other cells, such as bone, liver, and uterine cells”.

Pfizer bought Wyeth and now we are back to the Premarin horses with this new drug?  Premarin sales have been decreasing by the year due to the breast cancer risk so again the question here is the added SERMs going to make the drug safe for post menopause women?    Osteoporosis is also addressed with the drug.  BD 

Wyeth Used Ghostwriters - Video of the Premarin Horses

(Reuters) - U.S. health regulators approved Pfizer Inc's menopause drug Duavee, which the company hopes will reduce hot flashes with fewer side effects than older hormone-replacement therapies.

The Food and Drug Administration said on Thursday it approved the drug to treat women with moderate to severe menopause symptoms and to prevent post-menopausal osteoporosis, a bone disease which can increase the risk of fractures.

The drug, which Pfizer is developing with Ligand Pharmaceuticals Inc, combines bazedoxifene - which belongs to a class of drugs known as selective estrogen receptor modulators, or SERMS - and conjugated estrogens, which are derived from the urine of pregnant horses and contained in Pfizer's menopause drug Premarin.



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