Stem cells are taken from bone marrow and so far this has been tested in mice and the cells were engineered to produce IGF-1, a hormone for growth and it appears to be working in the lab to repair bone growth as well. The IGF-1 hormone is approved for children for growth failures currently and the combination with the stem cells might be something in the future that can help all of us out with fractures or broken bones. BD
(Embargoed) CHAPEL HILL, N.C. A Researchers at the University of North Carolina at Chapel Hill School of Medicine have shown in an animal study that transplantation of adult stem cells enriched with a bone-regenerating hormone can help mend bone fractures that are not healing properly.
The UNC study team led by Anna Spagnoli, MD, associate professor of pediatrics and biomedical engineering, demonstrated that stem cells manufactured with the regenerative hormone insulin-like growth factor (IGF-I) become bone cells and also help the cells within broken bones repair the fracture, thereby speeding the healing. The new findings are presented Sunday, June 5, 2011 at The Endocrine Society’s 93rd Annual Meeting in Boston, Massachusetts.
“More excitingly, we found that stem cells empowered with IGF-I restored the formation of new bone in a mouse lacking the ability to repair broken bones. This is the first evidence that stem cell therapy can address a deficiency of fracture repair,” she said.